Table 2.
(CAG)n and hormone concentrations by third wave (T3) frailty status
| Not frail (n = 251)
|
Intermediate (n = 286)
|
Frail (n = 46)
|
P value | ||||
|---|---|---|---|---|---|---|---|
| Mean | sd | Mean | sd | Mean | sd | ||
| (CAG)n | 22.1 | (2.97) | 22.1 | (3.09) | 22.3 | (2.58) | 0.897 |
| T1 | |||||||
| Testosterone (ng/dL) | 534.7 | (167.80) | 512.2 | (168.12) | 523.1 | (187.57) | 0.312 |
| FT (ng/dl) | 13.6 | (5.04) | 13.3 | (4.97) | 12.7 | (5.79) | 0.437 |
| SHBG (nm) | 32.6 | (16.79) | 31.5 | (16.79) | 34.3 | (15.11) | 0.489 |
| LH | 4.7 | (2.90) | 4.7 | (2.81) | 4.9 | (2.97) | 0.951 |
| T2 | |||||||
| Testosterone (ng/dl) | 472.1 | (154.96) | 442.5 | (156.35) | 442.1 | (165.66) | 0.078 |
| FT (ng/dl) | 11.2 | (3.75) | 10.4 | (3.63) | 9.0 | (3.37) | <0.001 |
| SHBG (nm) | 34.2 | (16.10) | 33.7 | (15.44) | 42.6 | (22.67) | 0.002 |
| LH | 5.5 | (3.60) | 5.8 | (5.10) | 6.2 | (4.95) | 0.511 |
| T3 | |||||||
| Testosterone (ng/dl) | 438.6 | (163.92) | 406.1 | (157.52) | 410.7 | (186.19) | 0.081 |
| FT (ng/dl) | 7.6 | (2.76) | 7.0 | (2.78) | 5.8 | (2.44) | <0.001 |
| SHBG (nm) | 50.8 | (19.86) | 50.7 | (19.76) | 63.5 | (22.70) | <0.001 |
| LH | 4.2 | (3.96) | 4.7 | (4.72) | 5.6 | (3.86) | 0.151 |
| Rate of change, T1 to T3 | |||||||
| Testosterone (ng/dl · yr) | −6.4 | (11.58) | −7.2 | (12.42) | −6.7 | (12.76) | 0.738 |
| FT (ng/dl/yr) | −0.4 | (0.31) | −0.4 | (0.37) | −0.4 | (0.33) | 0.643 |
| SHBG (nm/yr) | 1.2 | (1.25) | 1.3 | (1.38) | 2.0 | (1.46) | 0.003 |
| LH | −0.0 | (0.24) | 0.0 | (0.25) | 0.0 | (0.20) | 0.063 |