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Table 3.

Geometric means of inflammatory markers by diabetes status and HbA_1c quartile, adjusted for age, sex, race, Tanner stage, study site and BMI

	IL-6 (pg/ml)	hsCRP (mg/dl)	Fibrinogen (mg/dl)	Leptin (ng/dl)
Nondiabetic controls (n = 215)	3.0	0.047	280	5.7
T1D cases (n = 553)	7.9^a	0.075^b	366^a	5.7
T1D glycemia by quartile
Quartile 1 (n = 168): HbA_1c <7.2	8.2^a	0.061	360^a	6.7
Quartile 2 (n = 131): HbA_1c 7.2 to <8.3	7.6^a	0.076^b	359^a	6.1
Quartile 3 (n = 116): HbA_1c 8.3 to <9.3	7.5^a	0.074	363^a	6.4
Quartile 4 (n = 138): HbA_1c ≥9.3	8.1^a	0.092^a	383^a	4.2^b
P value for linear trend	0.71	0.04	0.04	N/A

T1D, Type 1 diabetes; N/A, not applicable.

P < 0.001 for comparison of T1D vs. control, adjusted for multiple comparisons (SAS simulation adjustment).

P < 0.05 for comparison of T1D vs. control, adjusted for multiple comparisons (SAS simulation adjustment).