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. 2010 Jun 10;2010:530745. doi: 10.1155/2010/530745

Figure 2.

Figure 2

Epithelial polarization is negatively impacted by MMP-7. (a) Analysis of MDCK polarization in response to the addition of basolateral or apical exogenous MMP-7 (100 ng/mL) to the lower or upper compartment of the transwell chamber, *P < .05 as determined by ANOVA followed by Bonferroni's post hoc test. Dashed line represents the resistance level at which MDCKs are polarized [7]. (b) Analysis of C57MG cell line transepithelial resistance in response to the expression of MMP-7. Confluent (day 8) MMP-7 expressing clones (M14 and M37) growing on a 0.4 μm transwell membrane never reached a resistance that was comparable to that of the empty vector control C57MG clones.