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. 2010 Jun 10;2010:530745. doi: 10.1155/2010/530745

Figure 5.

Figure 5

Epithelial proliferation is mediated by MMP-7 processing of E-cadherin. (a) Growth of the C57MG cell lines in the presence or absence of the broad spectrum metalloproteinase inhibitor (BB-94) over a 24-hour period was determined by MTT assay. Asterisk denotes that the proliferation of the MMP-7 expressing cell lines (M14/M37) is significantly higher than the empty vector controls (L2/L4), P < .05 while double asterisks denote that proliferation is significantly inhibited in the presence of BB-94 compared to the control conditions, P < .05. Significance was determined using ANOVA followed by Tukey's post hoc test. (b) The effect of E-cadherin on cell growth in the absence (IgG) or presence of an E-cadherin blocking antibody (α-E-cad) was measured using an MTT assay. Asterisk denotes significantly higher growth in the presence of the E-cadherin blocking antibody in comparison to the IgG treated controls, P < .05. Significance was determined using ANOVA followed by Tukey's post hoc test.