TABLE 1.
HCjE | HCorE | SF | TM | RPE | |
---|---|---|---|---|---|
Nectin-1 | +++/unknown | +++/unknown | −/− | −/− | +++/+++ |
HVEM | ++/unknown | ++/unknown | −/+++ | +++/unknown | ++/++ |
3O-S HS | +/− | −/− | +++/− | unknown/− | −/− |
PILR-α | −/unknown | +/unknown | unknown/unknown | unknown/unknown | +/− |
Note: The importance of receptors for entry are given for HSV-1 followed by HSV-2 for each ocular cell type. +++ means primary receptor, ++ means secondary receptor, + means co-receptor or otherwise less important for entry. A minus sign (−) denotes that either the receptor is not important for entry or it is not expressed. The unknowns are primarily for HSV-2 entry and PILR-α. HCjE = human conjunctival epithelial cells, HCorE = human corneal epithelial cells, SF = human corneal stromal fibroblasts, TM = human trabecular meshwork cells, RPE = human retinal pigment epithelial cells, HVEM = herpes virus entry mediator, 3O-S HS = 3-O sulfated heparan sulfate, PILR-α = paired immunoglobulin-like 2 receptor.