TABLE 1.

Importance for Entry of HSV-1/HSV-2 Receptors and Co-Receptors by Ocular Cell Type

	HCjE	HCorE	SF	TM	RPE
Nectin-1	+++/unknown	+++/unknown	−/−	−/−	+++/+++
HVEM	++/unknown	++/unknown	−/+++	+++/unknown	++/++
3O-S HS	+/−	−/−	+++/−	unknown/−	−/−
PILR-α	−/unknown	+/unknown	unknown/unknown	unknown/unknown	+/−

Note: The importance of receptors for entry are given for HSV-1 followed by HSV-2 for each ocular cell type. +++ means primary receptor, ++ means secondary receptor, + means co-receptor or otherwise less important for entry. A minus sign (−) denotes that either the receptor is not important for entry or it is not expressed. The unknowns are primarily for HSV-2 entry and PILR-α. HCjE = human conjunctival epithelial cells, HCorE = human corneal epithelial cells, SF = human corneal stromal fibroblasts, TM = human trabecular meshwork cells, RPE = human retinal pigment epithelial cells, HVEM = herpes virus entry mediator, 3O-S HS = 3-O sulfated heparan sulfate, PILR-α = paired immunoglobulin-like 2 receptor.