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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Mol Psychiatry. 2009 Aug 25;15(3):237–249. doi: 10.1038/mp.2009.80

Figure 1. Tianeptine regulates neuronal plasticity in the amygdala.

Figure 1

Rat dendritic arborization in the basolateral amygdale (BLA) increases after repeated chronic (10 days) immobilization stress. This stress-induced enhancement in dendritic arborization in BLA neurons is prevented by daily application of tianeptine (10mg/kg, i.p.). There is a significant decrease in the total dendritic length of BLA neurons from stressed animals treated by tianeptine (1770 ± 107μm) when compared to stressed animals the vehicle (2213 ± 59μm, p<0.001). A similar effect is seen in the number of branch points (15.6±0.9 number of branch points in stressed animals receiving vehicle versus 12 ± 1 in stressed animals treated by tianeptine).CIS:chronic immobilization stress ; Veh: vehicle. ***: p<0.001. Data are means ± SEM.