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. Author manuscript; available in PMC: 2010 Jul 12.
Published in final edited form as: J Neuroimmunol. 2010 Mar 5;221(1-2):46–52. doi: 10.1016/j.jneuroim.2010.02.011

Fig. 2.

Fig. 2

C5a alters ICAM expression in lupus brain. Immunofluorescence staining using anti-mouse CD54 antibody and detection with Alexa-594 labeled anti-rabbit antibody demonstrates a significant up-regulation of ICAM expression in MRL/lpr brain compared to control MRL+/+ brains. Shown are representative sections from each group. The staining is mainly present around the microvasculature as shown in the inset. The increase in expression of ICAM was reduced on C5aRant treatment. mRNA expression of ICAM as assessed by qRT-PCR was altered in brain in line with the observed protein changes. Values are expressed as Mean±S.D. *p<0.05.