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. 2010 Jun 23;30(25):8624–8636. doi: 10.1523/JNEUROSCI.5389-09.2010

Figure 7.

Figure 7.

Descending 5-HT depletion blocks intra-RVM ES-induced descending pain inhibition. Intra-RVM ES significantly induces transient increases of paw withdrawal latency, a measure of analgesia, during ES and at 5 min after ES compared to baseline at 3 d after gene transfer (#p < 0.05) in control shRNA-treated rats, which is completely eliminated in Tph-2 shRNA-treated rats. *p < 0.05; Tph-2 shRNA versus control shRNA treatment. Sham treatment for ES does not change thermal sensitivities in both control and Tph-2 shRNA-treated rats.