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. Author manuscript; available in PMC: 2010 Jul 12.
Published in final edited form as: Nat Genet. 2009 Jul 20;41(8):891–898. doi: 10.1038/ng.420

Figure 7. Effect of p53 depletion on ATRS/S cells and mice.

Figure 7

a, Relative number of cells alive on ATR+/+ and ATRS/S cultures after p53 depletion (see Methods). The number was normalized to cells infected with a control shRNA expressing lentivirus. b, Representative images of the type of abnormal nuclei found on p53 depleted Seckel MEF. Scale bar indicates 5 μm. Effect of p53 depletion on the G2 arrest (c) and γH2AX accumulation (d) observed on ATRS/S MEF. Scale bar indicates 100 μm. e, γH2AX IHC on a sagital section of a 13.5 dpc ATRS/S/p53−/−embryo. f, Magnification of a region close to the jaw on embryos from the different genotypes processed as in e. Scale bar indicates 50 μm.