Table 2.
Treatment Differences in Body Composition Measures Between the Drug Conservation (DC) and Viral Suppression (VS) Groups
| Outcome | Mean Change from Baseline to Month 12A |
Mean Change from Baseline through Month 36B |
||||||
|---|---|---|---|---|---|---|---|---|
| DC | VS | DC-VS | (95% CI) | P-Value | DC-VS | (95% CI) | P-Value | |
| Limb fat, absolute change (kg) | 0.20 | −0.13 | 0.34 | (−0.23, 0.90) | 0.25 | 0.13 | (−0.47, 0.73) | 0.67 |
| Limb fat, percent change (%)C | 9.0 | −0.8 | 9.8 | (3.5, 16.1) | 0.003 | 8.7 | (2.0, 15.4) | 0.01 |
| Lean limb mass (kg) | −0.29 | −0.18 | −0.11 | (−0.51, 0.29) | 0.60 | −0.03 | (−0.44, 0.39) | 0.90 |
| Total body fat (kg) | 0.45 | −0.23 | 0.68 | (−0.59, 1.95) | 0.29 | 0.17 | (−1.18, 1.52) | 0.81 |
| Lean body mass (kg) | −0.48 | −0.08 | −0.40 | (−1.11, 0.31) | 0.27 | −0.25 | (−0.99, 0.50) | 0.52 |
| VAT (cm2) | 3.5 | 5.5 | −2.1 | (−13.5, 9.4) | 0.72 | −1.0 | (−14.0, 12.0) | 0.88 |
| SAT (cm2) | 19.3 | 5.0 | 14.3 | (−0.1, 28.7) | 0.05 | 10.3 | (−4.6, 25.3) | 0.17 |
| Patient satisfaction with body imageD | −0.3 | −0.0 | −0.3 | (−6.8, 6.3) | 0.94 | −0.8 | (−6.8, 5.2) | 0.80 |
A
Adjusted for sex, race, and the sex-by-race interaction.
B
Estimates and p-values obtained in longitudinal mixed models adjusted for sex, race, and the sex -by-race interaction.
C
Percent change = (limb fat mass at follow-up visit limb fat mass at baseline)/(limb fat mass at baseline) * 100%.
D
Using a visual analogue scale from 0–100, with 0 being the worst and 100 the best.
Abbreviations: CI, confidence interval; DC, Drug Conservation group (episodic ART); SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; VS, Viral Suppression group (continuous ART)