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. Author manuscript; available in PMC: 2011 Jan 28.
Published in final edited form as: AIDS. 2010 Jan 28;24(3):353–363. doi: 10.1097/QAD.0b013e3283333666

Table 3.

Treatment Differences in Metabolic Parameters Between the Drug Conservation (DC) Versus Viral Suppression (VS) Groups.

Outcome Mean Change from baseline to Month 4A
 Mean Change from baseline through Month 12A
 Mean Change from baseline through Month 36A
Mean ChangeB
 DC-VS (95% CI) P DC-VS (95% CI) P Mean ChangeB
 DC-VS (95% CI) P
DC VS DC VS
Total cholesterol (mg/dl) −23.6 18.0 −41.7 (−53.8, −29.6) <0.001 −29.5 (−39.8, −19.3) <0.001 −21.6 6.4 −27.8 (−38.2, −17.5) <0.001
LDL-cholesterol (mg/dl) −13.2 5.5 −18.8 (−27.6, −9.9) <0.001 −12.0 (−19.3, −4.8) 0.001 −12.5 −0.1 −11.7 (−18.8, −4.5) 0.001
HDL-cholesterol (mg/dl) −3.4 3.2 −6.6 (−9.4, −3.8) <0.001 −6.6 (−9.3, −4.0) <0.001 −3.9 1.8 −6.0 (−8.6, −3.4) <0.001
Triglycerides (mg/dl) −29.0 44.7 −73.7 (−146, −1.2) 0.05 −63.6 (−109, −18) 0.01 −38.4 17.9 −57.2 (−98.8, −15.5) 0.01
Log Triglycerides −0.087 0.048 −0.14 (−0.20, −0.07) <0.001 −0.10 (−0.16, −0.05) <0.001 −0.08 0.03 −0.10 (−0.15, −0.04) <0.001
Lactate (mmol/l) −0.06 −0.16 0.10 (−0.14, 0.34) 0.42 0.11 (−0.14, 0.36) 0.39 −0.09 −0.17 0.09 (−0.13, 0.32) 0.41
C peptide (ng/ml) 0.21 −0.14 0.35 (−0.11, 0.80) 0.14 0.41 (0.08, 0.75) 0.02 0.41 0.08 0.37 (0.04, 0.75) 0.03
Insulin (μU/mL) 1.6 −1.3 2.9 (−1.8, 7.6) 0.23 2.8 (−1.1, 6.6) 0.16 3.2 1.4 1.88 (−1.6, 5.4) 0.29
Glucose (mg/dl) 6.4 −0.2 6.6 (−3.9, 17.1) 0.22 2.8 (−3.9, 9.5) 0.41 1.6 −1.9 2.78 (−3.4, 9.0) 0.38
HOMAC 0.57 −0.55 1.13 (−0.32, 2.57) 0.13 1.08 (−0.3, 2.5) 0.13 0.9 0.2 0.73 (−0.5, 1.9) 0.23
Hemoglobin A1c (%)D --- --- --- --- --- 0.3 (0.1, 0.5) 0.003 0.5 0.1 0.3 (0.1, 0.5) 0.02
A

Estimates and p-values were obtained in regression models (month 4) or longitudinal models (through months 12 and 36) which also contained race, sex, and the race-by-sex interaction.

B

Estimated means, covariate-adjusted for race, sex, and the race-by-sex interaction.

C

HOMA(homeostasis model assessment of insulin resistance) = (fasting plasma glucose [mmol/l]) * (serum insulin [mU/l])/22.5

D

Hemoglobin A1c was not measured at 4 months or 8 months. Through month 12, hemoglobin A1c increased by 0.3% in the DC group and had no change in the VS group.

Abbreviations: CI, confidence interval; DC, Drug Conservation group (episodic ART); HDL, high-density lipoprotein; HOMA, Homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; VS, Viral Suppression group (continuous ART);

To convert: mg/dL of cholesterol to mmol/L divide by 39; mg/dL of triglycerides to mmol/L divide by 89; mmol of lactate to mg/dL divide by 9; ng/mL of C peptide to nmol/L divide by 3; μU/mL of insulin to μg/L divide by 24; mg/dL of glucose to mmol/L divide by 18.