Table 3.
Univariate and multivariable Cox proportional hazard models of the primary composite event among subjects with and without HF
| Hazard ratio (95% CI) | P-value | |
|---|---|---|
| (a) Univariable model (n=1342, 90 excluded for missing information on HF) | ||
| Previous HF composite (HF, Cardiomyopathy, LVD, or RVD) vs no previous HF | 4.08 (3.09, 5.37) | <0.001 |
| (b) Unadjusted model with interaction (n=1342, 90 excluded for missing information on HF) | ||
| Hb 13.5 g/dl (vs 11.3 g/dl) | 1.73 (1.13, 2.65) | 0.011 |
| Previous HF composite (HF, Cardiomyopathy, LVD, or RVD) | 5.29 (3.45, 8.12) | <0.001 |
| Interaction of Hb 13.5 g/dl group and previous HF composite | 0.63 (0.36, 1.10) | 0.105 |
| Contrasts | ||
| No previous HF Patients—Hb 13.5 g/dl (vs Hb 11.3 g/dl) | 1.73 (1.13, 2.65) | 0.011 |
| Prior HF Patients—Hb 13.5 g/dl (vs Hb 11.3 g/dl) | 1.09 (0.76, 1.57) | 0.643 |
| (c) Adjusted multivariable model (n=1342, without missing HF with imputations for missing data in other fields) | ||
| Hb 13.5 g/dl (vs 11.3 g/dl) | 1.86 (1.21, 2.85) | 0.004 |
| Baseline albumin (g/dl) | 0.53 (0.40, 0.71) | <0.001 |
| Baseline cholesterol linear splines (per 10 mg/dl) | ||
| <240 mg/dl | 0.95 (0.92, 0.99) | 0.015 |
| ≥240 mg/dl | 1.09 (1.03, 1.16) | 0.003 |
| Age linear splines (per 5 years) | ||
| <55 years | 1.55 (1.12, 2.15) | 0.008 |
| ≥55 to <75 years | 0.97 (0.85, 1.10) | 0.591 |
| ≥75 years | 1.41 (1.17, 1.70) | <0.001 |
| Previous HF composite (HF, cardiomyopathy, LVD, or RVD) | 4.47 (2.89, 6.92) | <0.001 |
| Previous CVA or TIA | 1.42 (1.01, 2.00) | 0.042 |
| Previous DVT | 2.07 (1.20, 3.56) | 0.009 |
| History of solid organ malignancy | 0.64 (0.41, 0.99) | 0.046 |
| Previous atrial fibrillation/flutter | 1.77 (1.23, 2.54) | 0.002 |
| Interaction of Hb 13.5 g/dl group and previous HF composite | 0.53 (0.30, 0.94) | 0.028 |
| Contrasts | ||
| No previous HF patients—Hb 13.5 g/dl (vs Hb 11.3 g/dl) | 1.86 (1.21, 2.85) | 0.004 |
| Previous HF patients—Hb 13.5 g/dl (vs Hb 11.3 g/dl) | 0.99 (0.68, 1.43) | >0.999 |
For adjusted multivariable model, t-test P-values based on multiple imputation are provided. Otherwise, Wald χ2 P-values are reported.
DVT, deep vein thrombosis; LVD, left ventricular dysfunction; RVD, right ventricular dysfunction.