Skip to main content
. 2010 Jun 2;11(2):976–985. doi: 10.1208/s12249-010-9451-7

Table II.

Variables of Box–Behnken Design for Buspirone Transdermal Therapeutic Systems

Independent variables Levels used, actual (coded)
Low (−1) Medium (0) High (+1)
X 1 = HPMC K 4 M (g) 0.25 1.13 2
X 2 = d-limonene (mL) 4 8 12
X 3 = Propylene glycol (mL) 5 10 15