Table I.

Physicochemical Properties of Model Drugs

Properties	Drugs
	IBU	SA	DEX	5-FU
Molecular weight (g/mol)	206.27	138.12	392.46	130.08
Solubility in water (mg/ml)	0.098 ± 0.007	2.24 ± 0.16	0.11 ± 0.02	11.05 ± 0.93
Solubility in PG (mg/ml)	453.1 ± 37.6	201.6 ± 17.9	11.5 ± 1.4	6.1 ± 0.4
Solubility parameters ((J/cm3)1/2)a	20.91	31.33	28.58	62.72
Log K o/w	3.94 b	2.26b	0.72c	−0.86b
Melting point (°C)	74	157-159	256-260	283

IBU ibuprofen, SA salicylic acid, DEX dexamethasone, 5-FU 5-fluorouracil

Solubility in water or PG at 37°C

K _o/w is n-octanol/water partition coefficient at 37°C

^aCalculated using the method of Fedors (27)

^b(28)

^c(29)