Fig. 7.

Effect of kneading with water on dissolution profiles of IM from IM-HP-β-CyD system (a), IM-dicalcium phosphate system (b), IM-lactose monohydrate system (c) (equivalent to 50 mg of IM) in pH 6.8 phosphate buffer at 37°C. Unfilled circles physical mixture of IM and HP-β-CyD, filled circles kneaded sample for mixture of IM and HP-β-CyD, unfilled triangles physical mixture of IM and dicalcium phosphate, filled triangles kneaded sample for mixture of IM and dicalcium phosphate, unfilled squares physical mixture of IM and lactose monohydrate, filled squares kneaded sample of IM and lactose monohydrate. Each point represents the mean ± SD of three experiments