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Solubility of OLM Reference Substance at Different Dissolutions Media (40 mg OLM Bulk in 250 ml of Medium)
| Medium | Solubility (%) | |
|---|---|---|
| 1 h | 2 h | |
| 0.1 M HCl (pH 1.2) | 58.4 | 63.5 |
| 0.01 M HCl (pH 1.8) | 15.7 | 45.2 |
| USP pH 6.8 buffer | 34.7 | 38.5 |
| USP pH 7.5 buffer | 59.4 | 62.8 |
| H2O + 0.5% SLS pH 6.8 | 43.9 | 73.3 |
| H2O + 1.0% SLS pH 6.8 | 53.3 | 76.2 |
| H2O + 1.5% SLS pH 6.8 | 78.5 | 97.5 |
