Table V.
Kinetic Parameters for Different Release Models of OLM in Tablets Analyzed by LC-UV Method
| Dissolution model | Benicar® | Olmetec® |
|---|---|---|
| Zero-order k 0 | 3.0832 | 3.0433 |
| R 2 | 0.9742 | 0.9927 |
| MSC | 3.1587 | 4.4273 |
| First-order k 1 | 0.0523 | 0.0493 |
| R 2 | 0.9529 | 0.9285 |
| MSC | 2.5573 | 2.1393 |
| Higuchi k H | 14.4125 | 14.1377 |
| R 2 | 0.9219 | 0.8894 |
| MSC | 2.0498 | 1.7023 |
| Hixson–Crowell k HC | 0.0696 | 0.0663 |
| R 2 | 0.9756 | 0.9592 |
| MSC | 3.2171 | 2.6998 |
| Korsmeyers–Peppas k K | 0.0501 | 0.0322 |
| n | 0.8466 | 0.9820 |
| R 2 | 0.9844 | 0.9928 |
| MSC | 3.1634 | 3.9442 |
| t 50% (min) | 15.1 | 15.7 |
| t 80% (min) | 25.9 | 26.3 |
k 0, k 1, k H, k HC, k K release rate constants, MSC model selection criteria, n release exponent (indicative of drug release mechanism), t 50% dissolution half-life (zero-order kinetics), t 80% time to release 80% of the drug (zero-order kinetics)