Table I.
Formulation Design
| Variables | Values | Constants | |||||
|---|---|---|---|---|---|---|---|
| Zinc acetate concentration (% w/v) | Cross-linking solution pH | Cross-linking time (h) | Drying | Pectin concentration (% w/v) | Pectin–Resveratrol | ||
| Cross-linking agent | Zn | 5 | 1.5 | 0.5 | RT | 5 | 3:1 |
| Ca | 5a | 1.5 | 0.5 | RT | 5 | 3:1 | |
| Zinc acetate concentration (% w/v) | 1 | – | 1.5 | 0.5 | RT | 5 | 3:1 |
| 2.5 | – | 1.5 | 0.5 | RT | 5 | 3:1 | |
| 5 | – | 1.5 | 0.5 | RT | 5 | 3:1 | |
| 10 | – | 1.5 | 0.5 | RT | 5 | 3:1 | |
| Cross-linking pH | 1.5 | 5 | – | 0.5 | RT | 5 | 3:1 |
| 6.3 | 5 | – | 0.5 | RT | 5 | 3:1 | |
| Cross-linking time (h) | 0.25 | 5 | 1.5 | – | RT | 5 | 3:1 |
| 0.5 | 5 | 1.5 | – | RT | 5 | 3:1 | |
| 2 | 5 | 1.5 | – | RT | 5 | 3:1 | |
| 24 | 5 | 1.5 | – | RT | 5 | 3:1 | |
| Drying | RT | 5 | 1.5 | 0.5 | – | 5 | 3:1 |
| 37°C | 5 | 1.5 | 0.5 | – | 5 | 3:1 | |
| 50°C | 5 | 1.5 | 0.5 | – | 5 | 3:1 | |
| FD | 5 | 1.5 | 0.5 | – | 5 | 3:1 | |
| Pectin concentration (% w/v) | 3 | 5 | 1.5 | 0.5 | RT | – | 3:1 |
| 4 | 5 | 1.5 | 0.5 | RT | – | 3:1 | |
| 5 | 5 | 1.5 | 0.5 | RT | – | 3:1 | |
| 6 | 5 | 1.5 | 0.5 | RT | – | 3:1 | |
| Pectin–Resveratrol | 1:1 | 5 | 1.5 | 0.5 | RT | 5 | – |
| 2:1 | 5 | 1.5 | 0.5 | RT | 5 | – | |
| 3:1 | 5 | 1.5 | 0.5 | RT | 5 | – | |
| 4:1 | 5 | 1.5 | 0.5 | RT | 5 | – | |
| Blank | – | 5 | 1.5 | 0.5 | RT | 5 | – |
aCalcium chloride was used instead of zinc acetate