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. 2010 May 4;11(2):729–742. doi: 10.1208/s12249-010-9435-7

Table II.

Size, Shape, Weight, Zn Content, WL, MC, EE, and L of the Beads (Data Represents Mean ± SD (N = 3))

Variables Values Shape (ER)v Size (µm)v Weight of 50 beads (mg)v Zn content (µg mg−1 bead) MC (%) EE (%)
Cross-linking agent Zn 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92 10.09 ± 0.43k 97.99 ± 0.10k
Ca 1.07 ± 0.05 1,077.77 ± 72.97 32.62 ± 0.77 16.16 ± 1.00 98.65 ± 0.21
Cross-linking pH 1.5 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92a 10.09 ± 0.43 97.99 ± 0.10
6.3 1.06 ± 0.03 1,111.76 ± 40.61 24.49 ± 0.14 81.73 ± 0.94 11.05 ± 0.76 97.77 ± 0.68
Zinc acetate concentration (%) 1 1.03 ± 0.01 881.09 ± 38.29 19.84 ± 0.08 33.55 ± 0.87b 6.29 ± 0.95b 98.29 ± 0.12q
2.5 1.07 ± 0.02 886.96 ± 9.81 22.83 ± 0.11 50.44 ± 2.78 9.51 ± 0.66 98.01 ± 0.18
5 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92 10.09 ± 0.43 97.99 ± 0.10
10 1.06 ± 0.02 1,035.16 ± 43.22 25.54 ± 0.46 88.80 ± 0.60c 11.23 ± 0.79 97.68 ± 0.27
Cross-linking time (h) 0.25 1.13 ± 0.07 894.28 ± 14.38 20.38 ± 0.12 42.35 ± 2.94d 7.78 ± 0.19l 98.38 ± 0.04r
0.5 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92 10.09 ± 0.43m 97.99 ± 0.10s
2 1.07 ± 0.07 920.48 ± 14.47 23.24 ± 0.05 75.29 ± 0.96 12.25 ± 0.79 97.06 ± 0.85
24 1.10 ± 0.08 943.97 ± 15.04 24.74 ± 0.24 84.00 ± 0.91 13.21 ± 0.12 96.29 ± 0.11
Drying RT 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92e 10.09 ± 0.43e 97.99 ± 0.10
37°C 1.06 ± 0.03 895.76 ± 11.13 22.03 ± 0.73 54.65 ± 0.65f 9.56 ± 0.72f 97.99 ± 0.10
50°C 1.06 ± 0.03 886.88 ± 7.820 20.95 ± 0.51 85.30 ± 0.42 1.45 ± 0.45 97.99 ± 0.10
FD 1.06 ± 0.03 2,040.51 ± 46.66 19.59 ± 0.05 87.76 ± 0.61 0.66 ± 0.23 97.99 ± 0.10
Pectin concentration (%) 3 1.09 ± 0.03 892.87 ± 13.27 23.38 ± 0.98 116.25 ± 1.18g 10.70 ± 1.44 97.44 ± 0.08t
4 1.07 ± 0.03 898.47 ± 16.83 22.06 ± 0.55 96.02 ± 0.86h 11.01 ± 0.78 97.05 ± 0.09
5 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92 10.09 ± 0.43 97.99 ± 0.10
6 1.08 ± 0.03 907.63 ± 20.25 23.81 ± 0.18 53.43 ± 2.84 10.24 ± 0.72 97.75 ± 0.05
Pectin–Resveratrol 1:1 1.07 ± 0.03 1140.67 ± 80.12 40.16 ± 0.42 45.95 ± 2.05 15.07 ± 0.49n 99.28 ± 0.10u
2:1 1.07 ± 0.04 993.01 ± 48.82 31.57 ± 0.42 51.63 ± 2.10 12.43 ± 0.24o 98.55 ± 0.02
3:1 1.06 ± 0.03 896.44 ± 7.90 23.12 ± 0.03 54.12 ± 1.92 10.09 ± 0.43p 97.99 ± 0.10
4:1 1.05 ± 0.03 891.37 ± 11.06 21.81 ± 0.20 92.33 ± 0.24i 9.09 ± 0.07 97.50 ± 0.03
Blank 1.04 ± 0.01 866.62 ± 23.17 21.02 ± 0.09 111.58 ± 6.60j 8.54 ± 0.17

a p < 0.05 between cross-linking pH 1.5 and 6.3

b p < 0.05 between zinc acetate concentration 1% with 2.5%, 5%, and 10%

c p < 0.05 between zinc acetate concentration 10% with 2.5% and 5%

d p < 0.05 among cross-linking time 0.25, 0.5, 2, and 24 h

e p < 0.05 between drying at RT with 50°C and FD

f p < 0.05 between drying at 37°C with 50°C and FD

g p < 0.05 between pectin concentration 3% with 4%, 5%, and 6%

h p < 0.05 between pectin concentration 4% with 5% and 6%

i p < 0.05 between pectin to resveratrol ratio 4:1 with 1:1, 2:1, and 3:1

j p < 0.05 between blank beads with pectin to resveratrol ratio 1:1, 2:1, 3:1, and 4:1

k p < 0.05 between cross-linking agent Ca and Zn

l p < 0.05 between cross-linking time 0.25 h with 0.5, 2, and 24 h

m p < 0.05 between cross-linking time 0.5 h with 2 and 24 h

n p < 0.05 between pectin to resveratrol ratio 1:1 with 2:1, 3:1, 4:1, and blank

o p < 0.05 between pectin to resveratrol ratio 2:1 with 3:1, 4:1, and blank

p p < 0.05 between pectin to resveratrol ratio 3:1 with 4:1 and blank

q p < 0.05 between zinc acetate concentration 1% and 10%

r p < 0.05 between cross-linking time 0.25 h with 2 and 24 h

s p < 0.05 between cross-linking time 0.5 and 24 h

t p < 0.05 among pectin concentration 3%, 4%, 5%, and 6%

u p < 0.05 among pectin to resveratrol ratio 1:1, 2:1, 3:1, and 4:1

vStatistical analysis is not shown