Table I.

Physical Characterization of Rifampicin-Loaded mPEG–DSPE Nanoparticles

Formula code	Copolymer type	Filter porosity (μm)	Rifampicin conc. (mg/ml)	Drug/PEG–DSPE weight ratio (w/w)	Nanoparticles yield (% w/w)	Drug loading (% w/w)	Entrapment efficiency (% w/w)
F2	mPEG2000–DSPE	0.45	0.2	(1:5)	89.42 ± 4.19	19.30 ± 0.04	103.55 ± 0.19
F3	mPEG2000–DSPE	0.45	0.2	(1:10)	77.42 ± 2.52	11.40 ± 0.22	97.06 ± 1.87
F4	mPEG2000–DSPE	0.45	0.3	(1.5:10)	75.03 ± 1.76	14.52 ± 0.48	83.54 ± 2.79
F5	mPEG2000–DSPE	0.22	0.2	(1:5)	86.23 ± 8.66	19.58 ± 0.45	101.89 ± 2.34
F6	mPEG2000–DSPE	0.22	0.2	(1:10)	69.81 ± 1.69	12.56 ± 0.46	96.32 ± 3.49
F7	mPEG2000–DSPE	0.22	0.3	(1.5:10)	71.00 ± 0.97	15.95 ± 0.44	86.84 ± 2.42
F8	mPEG5000–DSPE	0.45	0.2	(1:5)	93.19 ± 1.57	18.65 ± 0.03	103.97 ± 0.14
F9	mPEG5000–DSPE	0.45	0.2	(1:10)	82.26 ± 0.38	10.72 ± 0.03	97.38 ± 0.26
F10	mPEG5000–DSPE	0.45	0.3	(1.5:10)	78.61 ± 3.16	14.33 ± 0.32	86.33 ± 1.95
F11	mPEG5000–DSPE	0.22	0.2	(1:5)	86.93 ± 8.97	19.58 ± 0.99	100.26 ± 5.07
F12	mPEG5000–DSPE	0.22	0.2	(1:10)	73.17 ± 1.24	12.18 ± 0.24	97.85 ± 1.92
F13	mPEG5000–DSPE	0.22	0.3	(1.5:10)	73.39 ± 0.91	15.18 ± 0.98	85.09 ± 5.47

Mean ± SD; N = 3