Table III.

Drug Release Kinetic Parameters of Rifampicin (Reference) and Rifampicin-Loaded-mPEG–DSPE Nanoparticles

Formula code	Formulations	Release rate constant		Correlation coefficient (r)	Higuchi (r)	T 50% (h)
		Zero-order k 0% (day−1)	First-order k 1 (day −1)
F1	Rifampicin	131.53 ± 16.14	–	0.9816 ± 0.07	0.9640 ± 0.04	10.98 ± 0.03
F2	R/mPEG2000–DSPE (1:5)/0.45	–	1.10 ± 0.07	0.9897 ± 0.01	0.9780 ± 0.01	17.06 ± 0.02
F3	R/mPEG2000–DSPE (1:10)/0.45	–	1.31 ± 0.22	0.9923 ± 0.01	0.9772 ± 0.01	16.52 ± 0.06
F4	R/mPEG2000–DSPE (1.5:10)/0.45	–	0.82 ± 0.03	0.9954 ± 0.01	0.9890 ± 0.01	20.88 ± 0.03
F5	R/mPEG2000–DSPE (1:5)/0.22	–	2.14 ± 0.05	0.9843 ± 0.02	0.9489 ± 0.02	11.78 ± 0.04
F6	R/mPEG2000–DSPE (1:10)/0.22	–	1.56 ± 0.26	0.9695 ± 0.03	0.9411 ± 0.02	10.95 ± 0.02
F7	R/mPEG2000–DSPE (1.5:10)/0.22	–	2.40 ± 0.25	0.9759 ± 0.02	0.9452 ± 0.03	12.83 ± 0.07
F8	R/mPEG5000–DSPE (1:5)/0.45	–	1.04 ± 0.08	0.9944 ± 0.01	0.9794 ± 0.01	20.10 ± 0.05
F9	R/mPEG5000–DSPE (1:10)/0.45	–	1.29 ± 0.21	0.9950 ± 0.01	0.9849 ± 0.01	18.54 ± 0.01
F10	R/mPEG5000–DSPE (1.5:10)/0.45	–	0.76 ± 0.02	0.9777 ± 0.03	0.9627 ± 0.03	22.10 ± 0.03
F11	R/mPEG5000–DSPE (1:5)/0.22	–	1.44 ± 0.31	0.9786 ± 0.01	0.9560 ± 0.02	12.94 ± 0.05
F12	R/mPEG5000–DSPE (1:10)/0.22	–	1.49 ± 0.02	0.9476 ± 0.03	0.9414 ± 0.01	11.74 ± 0.03
F13	R/mPEG5000–DSPE (1.5:10)/0.22	–	1.63 ± 0.52	0.9699 ± 0.04	0.9540 ± 0.02	13.63 ± 0.01

Mean ± SD; N = 3