Table III.
Changes of Particular Areas of HBS Formulations
| Formulation l-dopa + Metolose | Measured area | Time (min) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 | 30 | 45 | 60 | 75 | 90 | 105 | 120 | 135 | 150 | 165 | 180 | 195 | 210 | 225 | 240 | 255 | 270 | 285 | 300 | ||
| Metolose 65SH 400 | Total area | ➚Increase (nonlinear) | |||||||||||||||||||
| Hydrogel area | ➚Increase (linear), rate 0.28 mm2/min | ||||||||||||||||||||
| Dry core area | ➘ Decrease (linear), rate 0.23 mm2/min | ||||||||||||||||||||
| Metolose 90SH400 | Total area | ➚Increase (nonlinear) | ➘Decrease (nonlinear) | ||||||||||||||||||
| Hydrogel area | ➚Increase (linear), rate 0.29 mm2/min | ||||||||||||||||||||
| Dry core area | ➘Decrease (nonlinear) | ||||||||||||||||||||
| Metolose 65SH4000 | Total area | ➚Increase (nonlinear) | |||||||||||||||||||
| Hydrogel area | ➚Increase (linear), rate 0.24 mm2/min | ||||||||||||||||||||
| Dry core area | ➘Decrease (linear), rate 0.15 mm2/min | ||||||||||||||||||||
| Metolose 60SH10000 | Total area | ➚Increase (linear), rate 0.50 mm2/min | ➘Decrease (nonlinear) | ||||||||||||||||||
| Hydrogel area | ➚Increase (linear), rate 0.33 mm2/min | ||||||||||||||||||||
| Dry core area | ➚Increase (nonlinear) | ➘Decrease (linear), rate 0.19 mm2/min | |||||||||||||||||||