Skip to main content
. 2010 Apr 27;11(2):708–718. doi: 10.1208/s12249-010-9427-7

Table II.

Physical Evaluation of Trial Formulations

Physical evaluation of trial formulations
F1 F2 F3 F4 F5 F6 F7 F8 F9
Angle of repose (n = 3) 28.96 ± 1.78 26.97 ± 2.56 23.45 ± 1.15 27.13 ± 2.12 25.89 ± 2.35 26.76 ± 2.53 23.56 ± 1.22 24.54 ± 2.32 26.49 ± 3.08
% Carr’s Index (n = 3) 4.444 ± 1.45 7.317 ± 2.22 5.128 ± 1.34 2.778 ± 2.15 4.651 ± 1.33 4.762 ± 2.92 5.714 ± 1.65 2.500 ± 2.52 2.326 ± 2.16
Mean weight in mg (n = 20) 359.52 ± 15.22 340.32 ± 16.45 329.23 ± 13.22 331.54 ± 16.209 350.52 ± 16.78 342.54 ± 15.76 325.22 ± 14.23 350.82 ± 13.28 360.47 ± 12.65
Thickness in mm (n = 20) 2.34 ± 0.054 2.21 ± 0.098 2.08 ± 0.103 2.14 ± 0.063 2.28 ± 0.012 2.22 ± 0.013 2.06 ± 0.123 2.31 ± 1.44 2.37 ± 1.057
Diameter in mm (n = 20) 12.34 ± 0.021 12.12 ± 0.023 12.25 ± 0.015 12.31 ± 0.018 12.41 ± 0.107 12.35 ± 1.02 12.22 ± 0.015 12.37 ± 0.022 12.33 ± 0.019
Hardness in kg (n = 20) 12.54 ± 4.45 10.99 ± 3.62 10.68 ± 4.52 12.32 ± 5 12.55 ± 2.52 12.35 ± 5.54 11.55 ± 3.56 12.45 ± 4.25 12.49 ± 3.25
Friability in % (n = 10) 0.12 0.4 0.25 0.12 0.15 0.12 0.11 0.1 0.12
Content uniformity in % (n = 20) 89.55 92.68 95.58 90.69 87.98 88.78 91.08 88.82 87.56