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Hot Melt Extrusion Manufacturing Conditions and Resulting Potency Values
| Polymer | Particle size | Temperature (°C) | Screw speed (rpm) | Recirculation time (min) | Recovery (%) | Impurities (%) |
|---|---|---|---|---|---|---|
| Eudragit® L100-55 | Unmicronized | 140 | 300 | 2 | 22.7 ± 0.5 | 55.9 |
| Eudragit® L100-55 | Micronized | 140 | 300 | 0 | 69.1 ± 0.5 | 17.3 |
| HPMCAS | Unmicronized | 170 | 300 | 2 | 70.9 ± 0.3 | 10.2 |
| HPMCAS | Micronized | 170 | 300 | 0 | 78.4 ± 0.1 | 8.9 |
