Table IV.

The in vivo Sensory Analysis Panel (SAP) Scores Obtained for Reference Active Pharmaceutical Ingredients (APIs) at Each Concentration Used Either to Build or Validate the Bitterness Standard Model as Provided by Alpha M.O.S.

Reference APIs	Used to builda	Used to validatea	Concentration (mM)	In vivo score
Caffeine	√		0.24	2.5
			2.36	8.5
Paracetamol	√		3.31	4
			19.85	11
Quinine	√		0.03	9
			0.12	15.5
Prednisolone	√		0.44	13.5
			0.88	17
Loperamide		√	0.002	7.5
			0.01	14
Famotidine		√	0.06	4.2
			0.15	9

^aThe reference active pharmaceutical ingredients (APIs) that were used either to build or to validate the bitterness standard model