Table 2.

Tumor Characteristics and PET Parameters by Subtype

Characteristics	TN n=25	HER2 n=6	Luminal n=40	p-value Global difference by subtype§	Odds ratio, p-value TN vs Luminal‖
Tumor Grade
3 (versus 1 or 2)*	22 (88%)	4 (67%)	18 (45%)		8.7
95% CI†	(70%, 96%)	(30%, 90%)	(31%, 60%)	0.001	<0.001
Ki-67 proliferative index ‡
High (versus low or intermediate)	20 (95%)	3 (60%)	22 (63%)	0.01	11.4 0.009
95% CI†	(77%, 100%)	(23%, 88%)	(46%, 77%)
pCR
pCR (versus no or partial response)	7 (28%)	4 (67%)	5 (13%)	0.014	2.7 0.188
95% CI†	(14%, 48%)	(30%, 90%)	(5%, 26%)
MRFDG, µmol/min/100 g
Mean	15.9	7.58	9.72	0.009	0.019
SD	10.4	5.31	7.8
BF, mL/min/g
Mean	0.354	0.315	0.352	0.731	0.773
SD	0.148	0.129	0.214
MRFDG: BF ratio
Mean	44.3	24.1	28.7	0.004	0.011
SD	23	14.6	14.6

Abbreviations: TN, triple negative; pCR, pathologic complete response; MRFDG, metabolic rate of fluorodeoxyglucose; BF, blood flow; CI, confidence interval

^*5 luminal tumors were grade 1, others were grade 2

^†Confidence intervals computed using Wilson (score) method

^‡Missing values, n= 4 (TN), n=1 (Her2), n=5 (Luminal)

^§Fisher’s exact test for grade, Ki-67, pCR; likelihood ratio test for PET

^‖Odds ratio and Fisher’s exact test p-value for grade, Ki-67, pCR; Tukey-Kramer test for PET (difference not given for log-transformed variables)