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. 2008 Feb 22;29(5):964–970. doi: 10.1093/carcin/bgn056

Table III.

Association between MnSOD rs4880 T/C and MPO rs2333227 G/A genotypes and prostate cancer risk in 502 nested cases and 1354 controls from CARET cohort, 1985–1996

P for trend
MnSOD rs4880 TT TC CC TT+TC CC
    Control, N 327 635 317 962 317
    All cases, N 119 245 105 364 105
        OR (95% CI)1 1.0 (reference) 1.1 (0.8–1.4) 0.9 (0.7–1.3) 0.58 1.0 (reference) 0.9 (0.7–1.1)
    Nonaggressive cases, N 63 128 53 191 53
        OR (95% CI)2 1.0 (reference) 1.0 (0.7–1.5) 0.9 (0.6–1.3) 0.49 1.0 (reference) 0.8 (0.6–1.2)
    Aggressive cases, N 53 108 50 161 50
        OR (95% CI)2 1.0 (reference) 1.1 (0.7–1.5) 1.0 (0.7–1.5) 0.99 1.0 (reference) 1.0 (0.7–1.4)
MPO rs2333227 GG GA AA GG+GA AA
    Control, N 807 447 78 1254 78
    All cases, N 301 174 18 475 18
        OR (95% CI)1 1.0 (reference) 1.1 (0.9–1.3) 0.6 (0.4–1.1) 0.51 1.0 (reference) 0.6 (0.4–1.1)
    Nonaggressive cases, N 149 89 12 238 12
        OR (95% CI)2 1.0 (reference) 1.1 (0.8–1.5) 0.9 (0.5–1.6) 0.88 1.0 (reference) 0.8 (0.4–1.6)
    Aggressive cases, N 141 83 5 224 5
        OR (95% CI)2 1.0 (reference) 1.1 (0.8–1.5) 0.4 (0.2–1.0) 0.36 1.0 (reference) 0.4 (0.2–0.9)
a

The ORs in overall were estimated by unconditional logistic regression model adjusting for race, random assignment, family history of prostate cancer in first-degree relatives, alcohol consumption (non-drinker, below median, at or above median), smoking status (current versus former or never), smoking pack-year (<40, 40–60, ≥60), age at enrollment (continuous), BMI (<25.0, 25.0–29.9, ≥30.0), total energy intake (continuous, log transformed) and dietary antioxidants (carotenoids and vitamin C, continuous variables, log transformed).

b

The ORs among subgroups of cases according to disease status were tested by polychotomous logistic regression model adjusting for the same covariates listed above.