Table III.
P for trend | ||||||
MnSOD rs4880 | TT | TC | CC | TT+TC | CC | |
Control, N | 327 | 635 | 317 | 962 | 317 | |
All cases, N | 119 | 245 | 105 | 364 | 105 | |
OR (95% CI)1 | 1.0 (reference) | 1.1 (0.8–1.4) | 0.9 (0.7–1.3) | 0.58 | 1.0 (reference) | 0.9 (0.7–1.1) |
Nonaggressive cases, N | 63 | 128 | 53 | 191 | 53 | |
OR (95% CI)2 | 1.0 (reference) | 1.0 (0.7–1.5) | 0.9 (0.6–1.3) | 0.49 | 1.0 (reference) | 0.8 (0.6–1.2) |
Aggressive cases, N | 53 | 108 | 50 | 161 | 50 | |
OR (95% CI)2 | 1.0 (reference) | 1.1 (0.7–1.5) | 1.0 (0.7–1.5) | 0.99 | 1.0 (reference) | 1.0 (0.7–1.4) |
MPO rs2333227 | GG | GA | AA | GG+GA | AA | |
Control, N | 807 | 447 | 78 | 1254 | 78 | |
All cases, N | 301 | 174 | 18 | 475 | 18 | |
OR (95% CI)1 | 1.0 (reference) | 1.1 (0.9–1.3) | 0.6 (0.4–1.1) | 0.51 | 1.0 (reference) | 0.6 (0.4–1.1) |
Nonaggressive cases, N | 149 | 89 | 12 | 238 | 12 | |
OR (95% CI)2 | 1.0 (reference) | 1.1 (0.8–1.5) | 0.9 (0.5–1.6) | 0.88 | 1.0 (reference) | 0.8 (0.4–1.6) |
Aggressive cases, N | 141 | 83 | 5 | 224 | 5 | |
OR (95% CI)2 | 1.0 (reference) | 1.1 (0.8–1.5) | 0.4 (0.2–1.0) | 0.36 | 1.0 (reference) | 0.4 (0.2–0.9) |
The ORs in overall were estimated by unconditional logistic regression model adjusting for race, random assignment, family history of prostate cancer in first-degree relatives, alcohol consumption (non-drinker, below median, at or above median), smoking status (current versus former or never), smoking pack-year (<40, 40–60, ≥60), age at enrollment (continuous), BMI (<25.0, 25.0–29.9, ≥30.0), total energy intake (continuous, log transformed) and dietary antioxidants (carotenoids and vitamin C, continuous variables, log transformed).
The ORs among subgroups of cases according to disease status were tested by polychotomous logistic regression model adjusting for the same covariates listed above.