Table IV.
AKR1C3 and MTHFR haplotype frequencies among mothers and offspring with leukemia and control subjects and the adjusted ORs of the haplotypes to childhood leukemia risk
| Haplotypea | Motherb | Childc | ||||
| Case (%) | Control (%) | OR (95% CI)d | Case (%) | Control (%) | OR (95% CI)d | |
| AKR1C3 | ||||||
| G-A-G | 55 | 68 | 1 | 47 | 66 | 1 |
| T-G-A | 24 | 16 | 1.73 (1.15–2.61) | 26 | 17 | 2.18 (1.40–3.41) |
| G-G-G | 16 | 11 | 1.66 (1.02–2.70) | 19 | 11 | 2.54 (1.50–4.31) |
| G-A-A | 3 | 3 | 1.48 (0.50–4.40) | 4 | 3 | 1.99 (0.69–5.69) |
| Raree | 2 | 2 | 1.02 (0.32–3.21) | 4 | 3 | 1.35 (0.49–3.68) |
| MTHFR | ||||||
| C-A | 55 | 51 | 1 | 53 | 53 | 1 |
| T-A | 26 | 25 | 0.96 (0.65–1.42) | 27 | 24 | 1.12 (0.75–1.70) |
| C-C | 19 | 23 | 0.77 (0.51–1.18) | 20 | 22 | 0.88 (0.55–1.42) |
| Raree | 0 | 1 | NA | 0 | 1 | NA |
P-value of mother (haplotype T-G-A) = 0.009; P-value of mother (haplotype G-G-G) = 0.04; P-value of child (haplotype T-G-A) = 0.0006; P-value of child (haplotype G-G-G) = 0.0005.
AKR1C3 haplotype frequencies were presented by the sequences of rs2245191 G>T, rs10508293 A>G and rs3209896 G>A; MTHFR haplotype frequencies were presented by the sequences of rs1801133 C>T and rs1801131 A>C.
P-value of the global test for AKRIC3 = 0.05; for MTHFR = 0.60.
P-value of the global test for AKRIC3 = 0.0005; for MTHFR = 0.69.
ORs assessed by logistic regression adjusted for age and gender; assumed additive genetic model.
Combined rare haplotypes with frequencies <2% among the controls.