Table V.
The frequencies and adjusted OR of maternal and offspring's AKR1C3 polymorphisms stratified by MTHFR A1298C genotypes to the risk of childhood leukemia
| Polymorphism | MTHFR 1298AA | MTHFR 1298AC+CC | |||||||
| Case (%) | Control (%) | Adjusted OR (95% CI)a | P-value | Case (%) | Control (%) | Adjusted OR (95% CI)a | P-value | ||
| Offspring's | |||||||||
| AKR1C3 rs10508293 | AA | 17 (30.9) | 47 (50.0) | 1 | 7 (20.0) | 39 (54.9) | 1 | ||
| AG + GG | 38 (69.1) | 47 (50.0) | 2.30 (1.13–4.66) | 0.02 | 28 (80.0) | 32 (45.1) | 6.26 (2.27–17.28) | 0.0004 | |
| Maternal | |||||||||
| AKR1C3 rs10508293b | AA | 30 (43.5) | 54 (47.0) | 1 | 7 (20.0) | 40 (54.1) | 1 | ||
| AG + GG | 39 (56.5) | 61 (53.0) | 1.15 (0.63–2.10) | 0.66 | 28 (80.0) | 34 (45.9) | 4.75 (1.83–12.3) | 0.001 | |
a
ORs were assessed assuming additive genetic model. Analysis was adjusted for age and gender.
b
Significant interaction effect (nominal P-value < 0.05) according to the LRTs.