Figure 1.

Design of the study (A) The datasets from gene profiling of rat brain following stroke in the MCAO model and kainate-induced seizures were each separately transformed by SVD. (B) The eigenarrays resulting from the SVD of either dataset were compared by correlation analysis performed for the genes common between the two datasets. (C) For the emerging conserved eigensystems 2 and 3, separately for all the genes in either dataset, we studied their functional Gene Ontology (GO) associations and employed Bayesian Networks (BN) to study their cis-regulation. The results obtained on one dataset were then compared (GO) or statistically tested (BN) on the other.