Table 1.
Association analysis of genotype allele frequencies of RGS4 SNPs.
| Genotype freq. (N(%) | P | Allele freq. N(%) | P | |||||
|---|---|---|---|---|---|---|---|---|
| Controls | Alcoholics | Controls | Alcoholics | |||||
| SNP1 (rs10917670) | TT | 30 (0.259) | 20 (0.202) | T | 106 (0.457) | 89 (0.450) | ||
| TC | 46 (0.397) | 49 (0.495) | C | 126 (0.543) | 109 (0.550) | 0.8779 | ||
| CC | 40 (0.344) | 30 (0.303) | 0.3341 | |||||
| Total | 116 | 99 | ||||||
| SNP4 (rs951436) | AA | 31 (0.256) | 32 (0.304) | A | 115 (0.475) | 111 (0.529) | ||
| AC | 53 (0.438) | 47 (0.448) | C | 127 (0.525) | 99 (0.471) | 0.2578 | ||
| CC | 37 (0.306) | 26 (0.248) | 0.5572 | |||||
| Total | 121 | 105 | ||||||
| SNP7 (rs951439) | CC | 46 (0.377) | 29 (0.261) | C | 139 (0.570) | 116 (0.523) | ||
| CT | 47 (0.385) | 58 (0.523) | T | 105 (0.430) | 106 (0478) | 0.3071 | ||
| TT | 29 (0.238) | 24 (0.216) | 0.0834 | |||||
| Total | 122* | 111 | ||||||
| SNP18 (rs2661319) | AA | 27 (0.223) | 28 (0.259) | A | 107 (0.442) | 114 (0.528) | ||
| AG | 53 (0.438) | 58 (0.537) | G | 135 (0.558) | 102 (0.472) | 0.0671 | ||
| GG | 41 (0.339) | 22 (0.204) | 0.0723 | |||||
| Total | 121 | 108 | ||||||
*
Genotype distribution deviates significantly from Hardy-Weinberg equilibrium (P=0.018)