Table 1.
Expression changes in different cells after AC-1041 treatment.
| Code | Acc. No. | Gene product | K562 | HL60 | U266 | HT168 | U87 | HEPG2 | MCF7 |
|---|---|---|---|---|---|---|---|---|---|
| CCL2 | NM_002982 | Chemokine (C-C motif) ligand 2 | 0.31 | 0.35 | 0.37 | n.d. | 0.80 | 0.34 | 0.51 |
| ATF3 | NM_004024 | Activating transcription factor 3 | 10.21 | 2.75 | 8.17 | 18.29 | 4.10 | 0.66 | 4.32 |
| DDIT3 | NM_004083 | DNA-damage-inducible transcript 3 | 3.73 | 3.28 | 6.19 | 3.67 | 2.84 | 2.91 | 6.43 |
| LCRF | NM_153607 | Luman/CREB3 rercruitment factor | 4.19 | 10.02 | 2.02 | 12.49 | 2.38 | 2.45 | n.d. |
| DNAJB1 | NM_006145 | DnaJ (Hsp40) homolog B1 | 10.14 | 3.23 | 4.15 | 10.41 | 5.93 | 5.67 | 2.09 |
| HERPUD1 | NM_014685 | ER stress-inducible, ubiquitin-like 1 | 2.76 | 1.76 | 1.02 | 7.63 | 2.57 | 3.81 | 2.03 |
| HSPH1 | NM_006644 | Heat shock 105kDa/110kDa protein 1 | 3.64 | 2.69 | 1.70 | 3.26 | 1.88 | 2.27 | 0.89 |
| TP53 | NM_000546 | Tumor protein p53 | 2.37 | 7.62 | 1.07 | 1.31 | 1.01 | 1.05 | 4.02 |
| ING3 | NM_019071 | Inhibitor of growth family, member 3 | 1.63 | 2.10 | 1.80 | 1.92 | 1.59 | 0.72 | 2.51 |
| LATS2 | NM_014572 | LATS, large tumor suppressor, homolog 2 | 2.62 | 1.73 | 1.20 | 3.57 | 2.11 | 0.24 | 0.65 |
| CCND1 | NM_053056 | Cyclin D1 | 0.46 | 1.13 | 1.00 | 0.85 | 1.19 | 2.12 | 1.12 |
| DUSP1 | NM_004417 | Dual specificity phosphatase 1 | 3.77 | 1.30 | 5.29 | 0.94 | 1.66 | 0.94 | 1.62 |
| DUSP8 | NM_004420 | Dual specificity phosphatase 8 | 9.23 | 5.81 | 7.94 | 1.01 | 2.68 | 1.91 | 1.80 |
| DUSP10 | NM_007207 | Dual specificity phosphatase 10 | 2.86 | 2.22 | 2.05 | 0.81 | 1.30 | 1.21 | 3.35 |
| SNX16 | NM_022133 | Sorting nexin 16 | 3.19 | 3.07 | 1.39 | 1.07 | 0.75 | 1.24 | 1.92 |
Down-regulated gene expression values (<1.80-fold) are indicated by bold, underlined numbers, induced expression values (>1.80-fold) by bold and italics.