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. Author manuscript; available in PMC: 2011 Aug 5.
Published in final edited form as: Mol Cell Endocrinol. 2010 Jan 18;324(1-2):51–63. doi: 10.1016/j.mce.2010.01.017

Fig. 4.

Fig. 4

The reproductive circuits of prepubertal (PND 16–18) male mice are suppressed by both gonadal steroids and gonadal steroid-independent factors. In contrast, reproductive circuits in prepubertal females and adults of both sexes are predominantly suppressed by gonadal steroids. Gonadectomy (removing hormone negative feedback) therefore increases ARC Kiss1 levels in adults and prepubertal females, but not prepubertal males (who still have gonad-independent restraint mechanisms present). It is unknown if this sex difference relates to sex differences in pubertal maturation.