Figure 1.
(A) Enteroendocrine (chromogranin positive) cell and (B) enterochromaffin (5-HT positive) cell counts in the gastric mucosa of patients with functional dyspepsia (FD) are similar as compared to control subjects and subjects with organic diseases. (C) Enteroendocrine (chromogranin positive) cell and (D) enterochromaffin (5-HT positive) cell counts in the rectal mucosa of patients with irritable bowel syndrome (IBS), control subjects and subjects with organic diseases with inflammation grading ≥ 2 (Inflammed organic disorders) and without inflammation (Non-inflammed organic disorders). No significant differences were detected in enteroendocrine and enterochromaffin cell counts of samples from patients with IBS as compared to controls. Biopsies with inflammation grading ≥ 2 obtained from subjects with organic disease exhibited significant lower enteroendocrine and enterochromaffin cell counts as compared to controls and biopsies without inflammation (grade ≤ 1).