Table 4.

Association between ≥2 years supply of proton pump inhibitors and the risk of hip fracture, stratified by time since most recent prescription.

	User Status	Interval Since Last Prescription1	Cases	Controls	Adjusted Odds Ratios 95% Confidence Intervals2
No Use			84,913	20,498	Reference
≥2 years supply	All Users	All Persons with ≥2 years supply	1558	4806	1.30 (1.21 – 1.39)
Current vs. Former Users3	Current User	Prescription in last year	1288	3958	1.30 (1.21 – 1.41)
	Recent User	Last Prescription 1–1.9 years prior	73	220	1.24 (0.90 – 1.72)
	Former User	Last Prescription 2–2.9 years prior	23	84	1.09 (0.64 – 1.85)
	Former User	Last Prescription 3–5.9 years prior	15	87	0.69 (0.37 – 1.28)

¹Time between index date and last PPI prescription among persons with ≥2 years supply of proton pump inhibitors prior to their index date. A current user, for example, would have received at least one prescription in the year prior to hip fracture (or the comparable index date for controls)

²Cases and controls were individually matched for sex, age, duration of membership, first year of membership, and race/ethnicity; models were adjusted for a smoking diagnosis.

³Among subjects with ≥2 years supply