Table 1.
Baseline Characteristics
| Characteristics | ESPRIT | SILCAAT | Overall |
|---|---|---|---|
| No. of patients | 2040 | 984 | 3024 |
| Gender-Male (%) | 1659 (81.0) | 829(84.0) | 2488(82.3) |
| Mean age in years(SD) | 41(9.1) | 42(8.7) | 41 (9.0) |
| Race/Ethnicity (%) | |||
| Asian | 220 (10.8) | 12(1.2) | 232(7.7) |
| Black | 180(8.9) | 90(9.1) | 270(9.0) |
| White | 1541(75.8) | 774(78.6) | 2315(76.8) |
| Other/Unknown | 90(4.4) | 108(11.0) | 198(6.6) |
| Mean CD4 count (SD) | 495 (169.3) | 201.7(72.0) | 400 (200.0) |
| Mean nadir CD4 count (SD) | 211(152.0) | 73.45(58.2) | 166.63 (144.6) |
| Mean CD4% at baseline (SD) | 24.84 (8.5) | 15 (6.0) | 21.5(9.0) |
| HIV RNA copies/mL (%) | |||
| ≤500 | 1637(80.4) | 801(81.5) | 2438(80.8) |
| 500–10,000 | 278(13.6) | 164(16.6) | 442(14.6) |
| >10,000 | 121(5.9) | 18(1.83) | 139(4.6) |
| History of Prior AIDS at baseline (%) | 541(26.5) | 306(31.2) | 847(28.0) |
| Mean ART duration in months (SD) | 56.5(38.4) | 59.4(42.8) | 57.4 (39.8) |
| ARV categories at baseline (%): | |||
| NRTI | 2000(98.2) | 971(98.8) | 2971(98.4) |
| NNRTI | 977(48.0) | 455(46.3) | 1432(47.4) |
| PI | 968(47.5) | 630(64.0) | 1598 (53.0) |
| Other | 13(0.6) | 3(0.3) | 16(0.5) |
| Likely Infection mode$ (%) | |||
| IV drug abuse | 205(10.0) | ||
| MSM | 1136(55.7) | ||
| Heterosexual sex | 766(37.5) | ||
| Blood products | 36(1.8) | ||
| Other | 37(1.8) | ||
| Unknown | 73(3.6) | ||
| Hep B Positive$(%) | 127(7.2) | ||
| Hep C Positive$(%) | 268(15.6) | ||
$
These variables were not available for SILCAAT trial and were therefore not included as covariates in Cox regression analysis. SD= Standard deviation.
CD4= CD4+ T-cells/mm3, unless otherwise stated.