Figure 1.

Agonistic anti-CD137 Ab treatment increases CD11b⁺Gr-1⁺ cells in spleen. Naïve BALB/c mice were intraperitoneally (i.p) injected with 300µg of anti-CD137 Ab (3H3) or rIgG control Ab. Five days later, the percentage (A) and number (B) of CD8⁺ T cells (CD3ε^-CD8α⁺), CD4⁺ T cells (CD3ε^-CD4⁺), B cells (B220⁺CD3ε^-), NK cells (CD49b⁺CD3ε^-), CD11c⁺CD8α⁺ cells and CD11b⁺Gr-1⁺ cells in splenocytes were examined (n=3~4/group). ^*p<0.05, ^**p<0.005, ^†p<0.001. Data are representative of at least three separate experiments.