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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Acta Biomater. 2010 Mar 18;6(9):3426–3435. doi: 10.1016/j.actbio.2010.03.020

Figure 7.

Figure 7

(a and b) Cumulative change of Ca2+ amount and (c and d) plasmid DNA release efficiency released from Ca-P mineral coatings grown on pre-hydrolyzed PLG films in 2 ×, 3.5 ×, or 5 × SBF solution after 3 weeks of incubation in 0.05 M Pipes-buffered solutions containing 0 ×, 0.3 ×, 0.6 ×, or 1 × of physiologic [Ca2+] and [PO43−] at pH 7.4 (a and c) and in 0.05 M acetate-buffered solution at pH 4 and 5 or in 0.05 M Pipes-buffered solution at pH 6 and 7.4 with 1 × of physiologic [Ca2+] and [PO43−] (b and d). plasmid DNA release efficiency is defined by the percentage of cumulative plasmid DNA amount released after 3 weeks of incubation relative to the amount of plasmid DNA initially bound. The cumulative change of Ca2+ amount and the plasmid DNA release efficiency were each dependent on intrinsic mineral properties. * indicates statistical significance (p < 0.05).