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. Author manuscript; available in PMC: 2010 Jul 13.
Published in final edited form as: Trends Neurosci. 2010 Apr 1;33(7):307–316. doi: 10.1016/j.tins.2010.03.002

Figure 2. Structure and function of dendritic HCN channels.

Figure 2

A) Illustration of TRIP8b and PEX5Rp interaction with the C-terminus of HCN subunits. The Cyclic Nucleotide Binding Domain (CNBD) which binds to cAMP is also located on the C-terminus. B) Confocal images showing TRIP8b and HCN1 expression in cortical layer V cell dendrites. The right panel shows the merged image of rhodamine-red labelled anti-TRIP8b and FITC labelled anti-HCN1. Co-localization is depicted as yellow on this image. The double staining was obtained in the same brain section (adapted from Ref. [92]).