Skip to main content
. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Transplant Rev (Orlando). 2010 Jun 11;24(3):147–159. doi: 10.1016/j.trre.2010.04.002

Figure 1. CD4+ CD25+ Treg Cell Development in the Thymus and Periphery.

Figure 1

Development of CD4+ CD25+ Tregs's in the thymus involves interaction with thymic stromal cells via various molecules. An alternative model suggests clonal deletion as the predominant Treg developing mechanism within the thymus. In the periphery the majority of Treg's constitutively express high levels of Foxp3. The CD25 low Tregs's undergo homeostatic proliferation and/or Issue infiltration. Both CD25 high and CD25 low Treg's are immunosuppressive and express Foxp3.