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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Transplant Rev (Orlando). 2010 Jun 11;24(3):147–159. doi: 10.1016/j.trre.2010.04.002

Figure 3. CD4−CD8− (double-negatve, DN) T-cells.

Figure 3

Although only 1–5% in periperal lymphoid Issues, DN Treg's are potent in inhibiting allo und autoimmune responses in an antigen specific manner. In murine models DNT can be derived directly from CD8+ T cells, or arise extrathymicly from bone marrow.