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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cell Immunol. 2010 May 4;264(1):54–60. doi: 10.1016/j.cellimm.2010.04.011

Fig 1.

Fig 1

IgE suppresses IL-12 production in vivo and in vitro. (A) Splenocytes and cells from collagenase digested lung from 12 week old WT and LT−/− mice were stimulated with LPS for 24 hours. After 24 hours supernatant was collected and subjected ELISA to measure IL-12p70. *** P<0.0001, ** P=0.0007 and * P<0.040. (B) APC from RAG-1−/− spleens and LN were sensitized with or without 5 ug/ml anti-DNP IgE on DNP-HSA coated plates. After 24 hours supernatant was collected and subjected ELISA to measure IL-12p70. Data are reported as a mean and representative of at least 4 experiments where *** P<0.0004 and ** P=0.0010.