TABLE 1.
DETAILS OF LESIONS ANALYZED AND CORRESPONDING STUDY PATIENTS
| Lesion Number | Patient Code | Sex | Age at Enrollment, yr | Pack-years* | Smoking Status at Enrollment in Study | Prior Lung Cancer | Duration Follow-up | Contemporaneous or Subsequent Lung Cancer | Same or Remote Anatomical Site | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| LG1 | 006† | M | 60 | 141 | Ex | N | 18 | No | N/A | Alive, free from lung cancer† |
| LG2 | 008 | M | 61 | 96 | Ex | N | 18 | No | N/A | Alive, free from lung cancer |
| LG3 | 019 | M | 70 | 60 | Current | N | 46 | No | N/A | Alive, free from lung cancer |
| LG4 | 020 | M | 53 | 45 | Current | N | 39 | No | N/A | Alive, free from lung cancer |
| LG5 | 064 | M | 52 | 30 | Current | N | 49 | No | N/A | Alive, free from lung cancer |
| LG6,7‡ | 073 | M | 53 | 33 | Ex | N | 25 | No | N/A | Alive, free from lung cancer |
| HG1 | 002 | F | 71 | 100 | Ex | N | 66 | Yes | Same | “Curative” surgical resection at month 13. Disease free for >5 yr post resection. Died year 9 from lung cancer |
| HG2 | 006† | M | 60 | 141 | Ex | N | 53 | Yes | Same | †Surgical resection. Alive, free from lung cancer |
| HG3 | 076 | M | 58 | NR | Ex | N | 15 | Yes | Same and remote | Recent diagnosis (2009) lung cancer |
| HG4 | 012 | M | 65 | 60 | Ex | Y | 46 | No | N/A | Alive, free from lung cancer |
| HG5 | 017 | M | 66 | NR | Ex | Y | 17 | Yes | Remote | Died, complications of treatment for lung cancer (PDT) |
| HG6 | 024 | M | 73 | 96 | Ex | Y | 17 | Yes, contemporary | Remote | PDT to cancer and high-grade lesion. Alive, free from lung cancer |
| HG7 | 026 | M | 74 | 40 | Ex | Y | 42 | Yes | Remote | Dead, lung cancer |
| HG8 | 056 | M | 70 | 65 | Ex | N | 48 | Yes | Not known | Dead, lung cancer |
| HG9 | 060 | M | 69 | 26 | Ex | N | 51 | Yes, contemporary | Adjacent | Treated with PDT. Alive, recurrent disease treated endobronchially |
| HG10 | 061 | M | 78 | 80 | Ex | Y | 9 | No | N/A | Unknown |
Definition of abbreviations: N/A = not applicable; NR = not recorded; PDT = photodynamic therapy.
*
Pack-year: 20 cigarettes per day for 1 year.
†
Patient 006 had a left upper lobe lesion (HG2) and subsequently developed a squamous carcinoma of the left upper lobe. LG1 is a biopsy taken from a lesion subsequently detected at a surveillance bronchoscopy in the contralateral lung (right lower lobe).
‡
Patient had multifocal low-grade disease. Lesion LG7 was read as squamous metaplasia by the reference thoracic pathologist.