Table 2.
MCI Progress and MCI Stable group means (SDs) for each of the neuropsychological tests.
| Group Mean Scores | |||
|---|---|---|---|
| Test Measure | Progress (n=13)* | Stable (n=27)* | p Value† |
| Rey-Osterrieth Complex Figure (Rey, 1941; Osterrieth, 1944) | |||
| Copy Score | 26.8(7.4) | 30.8(3.9) | NS |
| Immediate Recall Score | 4.3(5.2) | 10.6(6.8) | <0.01 |
| Delayed Recall Score | 5.2(5.5) | 9.5(7.2) | NS |
| Mini-Mental State Examination (Folstein et al., 1975) | |||
| Score | 25.0(3.2) | 27.1(2.5) | NS |
| WMS-III Digit Span (Wechsler, 1997) | |||
| Forward Score | 6.3(1.1) | 6.3(1.0) | NS |
| Backward Score | 4.8(1.0) | 5.0(1.3) | NS |
| Letter-Number Sequencing | 4.5(1.3) | 5.0(1.3) | NS |
| Geriatric Depression Scale (Yesevage et al., 1983) | |||
| Score | 7.2(7.7) | 6.5(4.6) | NS |
| WMS-R Logical Memory I (Wechsler, 1945; Wechsler, 1987) | |||
| Total Recall Score | 23.2(11.5) | 34.7(10.7) | <0.01 |
| WMS-R Logical Memory II (Wechsler, 1945; Wechsler, 1987) | |||
| Total Recall Score | 9.2(10.8) | 17.6(9.9) | NS |
| Recognition Score | 20.9(5.3) | 24.1(3.9) | NS |
| Clock Drawing Test (Tuokko et al., 1992) | |||
| Score | 18.5(1.3) | 18.6(2.3) | NS |
| North American National Adult Reading Test (Grober and Sliwinski, 1991) | |||
| Score | 38.2(7.2) | 37.3(8.3) | NS |
| Stroop Test (Golden, 1978) | |||
| Color-Word Score | 26.6(10.8) | 27.3(9.3) | NS |
| Brief Visuospatial Memory Test-Revised (Benedict and Groninger, 1995) | |||
| Total Recall Score | 7.5(5.2) | 12.7(7.7) | NS |
| Delayed Recall Score | 2.1(2.1) | 4.5(3.4) | NS |
| Discrimination Index | 4.6(1.6) | 4.4(1.3) | NS |
| Controlled Oral Word Association Test (Benton and Hamsher, 1976) | |||
| Total Score (F, A, S) | 34.5(17.2) | 37.6(12.4) | NS |
| Category Fluency (Benton and Hamsher, 1976) | |||
| Score (animal naming) | 13.4(5.7) | 16.5(5.3) | NS |
| Blessed Dementia Scale (Blessed et al., 1968) | |||
| Score | 1.8(1.8) | 1.3(1.4) | NS |
| Hopkins Verbal Learning Test (Brandt, 1991) | |||
| Total Recall Score | 17.1(5.9) | 23.0(5.2) | <0.01 |
| Delayed Recall Score | 2.9(4.0) | 6.3(3.2) | <0.01 |
| Discrimination Index | 6.7(3.6) | 9.5(2.1) | <0.01 |
| Boston Naming Test (Kaplan et al., 1978; Mack et al., 1992) | |||
| Score (15 item maximum) | 13.8(1.2) | 14.3(0.8) | NS |
| Standardized Road-Map Test of Direction (Money, 1976) | |||
| Score | 26.7(7.4) | 25.6(7.3) | NS |
| Trail Making Test (Reitan, 1958) | |||
| Trail A Score (in seconds) | 52.8(22.3) | 40.6(12.4) | NS |
| Trail B Score (in seconds) | 182.3(118.9) | 109.0(54.7) | NS |
*
Two members of the Progress group and one member of the Stable group did not complete the neuropsychological battery, leaving 40 MCI individuals contributing to the group means reported.
†
In order to maintain a significance level of 0.05 for the entire family of neuropsychological tests, the Bonferroni adjustment would result in p < 0.002 for each individual test; using this, no test reached statistical significance at this level. Because the Bonferroni is often considered too conservative, a two-tailed p level < 0.01 was selected. NS = not significant.