Table 2. Hazard ratios (HR) (95% CI) of venous thromboembolism for quintiles, per standard deviation decrement, and for very low (<5 percentile) baseline serum albumin levels, ARIC, 1987-2005.
| Range (g/L) N |
HR (95% CI) per Albumin Quintile | HR (95% CI) per SD Decrement of Albumin (2.7 g/L) | HR (95% CI) for Bottom 5% of Albumin vs Top 95% | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Q1 20-36 2908 |
Q2 37-38 4128 |
Q3 39 2407 |
Q4 40 3703 |
Q5 41-51 2154 |
Trend p-value | ||||
| Total VTE | N events | 104 | 151 | 77 | 37 | 93 | 462 | 462 | |
| Model 1 | 1.57 (1.18, 2.10) | 1.54 (1.19, 2.00) | 1.32 (0.97, 1.78) | 0.74 (0.51, 1.09) | 1.00 | <0.0001 | 1.26 (1.15, 1.39) | 1.66 (1.18, 2.33) | |
| Model 2 | 1.35 (1.00, 1.82) | 1.47 (1.13, 1.92) | 1.29 (0.95, 1.74) | 0.73 (0.50, 1.07) | 1.00 | 0.0007 | 1.18 (1.08, 1.31) | 1.28 (0.90, 1.84) | |
| Model 3 | 1.24 (0.91, 1.68) | 1.42 (1.09, 1.85) | 1.26 (0.93, 1.71) | 0.73 (0.50, 1.07) | 1.00 | 0.005 | 1.15 (1.04, 1.27) | 1.15 (0.79, 1.66) | |
| Idiopathic VTE | N events | 36 | 64 | 28 | 11 | 31 | 170 | 170 | |
| Model 1 | 1.60 (0.98, 2.61) | 1.93 (1.25, 2.98) | 1.43 (0.85, 2.38) | 0.66 (0.33, 1.31) | 1.00 | 0.001 | 1.28 (1.09, 1.49) | 1.91 (1.13, 3.22) | |
| Model 2 | 1.36 (0.82, 2.25) | 1.82 (1.18, 2.82) | 1.39 (0.83, 2.33) | 0.64 (0.32, 1.27) | 1.00 | 0.009 | 1.19 (1.02, 1.40) | 1.50 (0.86, 2.61) | |
| Model 3 | 1.17 (0.70, 1.98) | 1.73 (1.11, 2.68) | 1.35 (0.81, 2.26) | 0.63 (0.32, 1.26) | 1.00 | 0.04 | 1.13 (0.96, 1.33) | 1.25 (0.70, 2.21) | |
| Secondary VTE | N events | 68 | 87 | 49 | 26 | 62 | 292 | 292 | |
| Model 1 | 1.57 (1.10, 2.24) | 1.35 (0.97, 1.88) | 1.27 (0.87, 1.85) | 0.79 (0.50, 1.24) | 1.00 | 0.0002 | 1.26 (1.12, 1.41) | 1.53 (0.98, 2.38) | |
| Model 2 | 1.36 (0.94, 1.96) | 1.30 (0.93, 1.81) | 1.24 (0.85, 1.81) | 0.78 (0.49, 1.23) | 1.00 | 0.02 | 1.18 (1.04, 1.33) | 1.16 (0.72, 1.86) | |
| Model 3 | 1.29 (0.88, 1.87) | 1.27 (0.91, 1.77) | 1.22 (0.83, 1.78) | 0.78 (0.49, 1.23) | 1.00 | 0.05 | 1.16 (1.02, 1.31) | 1.08 (0.67, 1.76) | |
Model 1: Adjusted for age (continuous), sex, and race (African American, other)
Model 2: Adjusted for age (continuous), sex, and HRT use (3-level categorical variable), race, diabetes status (yes, no), history of cancer (yes, no), eGFR (continuous), and BMI (continuous)
Model 3: Adjusted for Model 2 + Factor VIII (continuous), aPTT (continuous), and fibrinogen (continuous)
Abbreviations: aPTT, activated partial thromboplastin time; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; eGFR, estimated glomerular filtration rate; HR, hazard ratio; HRT, hormone replacement therapy; VTE, venous thromboembolism