Figure 2.
IFN-γ primes cultured VSMCs for inflammatory responses to dsRNA. (A) PBMCs, (B) ECs, and (C) VSMCs were primed or not with IFN-γ at 40 ng/mL for 72 hr followed by treatment with medium alone (None), LPS, R848, or poly(I:C) at 1 μg/mL, delivered with or without lipofectamine, for 48 hr. TNF-α and IP-10 supernatant levels were measured by ELISA. Data are means ± SE (n = 4 for PBMCs and n = 8 for ECs and VSMCs). *P < 0.05 Treated vs. None and #P < 0.05 IFN-γ-primed vs. Unprimed.