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. 2003 Dec 1;31(23):6710–6721. doi: 10.1093/nar/gkg913

Figure 8.

Figure 8

A model depicting the dynamic transcription factor complexes found at the proximal region of the mouse MT-I promoter. (A) ‘Basal’ or uninduced complex. (B) Metal-induced complex. The approximate positions of base pairs (–230 to –40 bp) relative to the transcription start site are indicated. The multiple MREs are indicated (a–e), and the other promoter elements shown here are described in the text and in the legend to Figure 1. An open box indicates the site of a constitutive in vivo footprint downstream of E-box 1, and an open circle with a question mark inside indicates an unidentified transcription factor(s) that binds to this sequence. The apparently weaker or transient association of MTF-1 with multiple MREs under basal conditions is indicated using a double-headed arrow in (A). In contrast, all the MREs are occupied under metal-induced conditions (B). USF-1, USF-2 and Sp1 binding sites are indicated. Protein–protein and protein–DNA interactions for fos and jun are not well-defined and are indicated by arrows with question marks. The looping of the promoter DNA is hypothetical.