Fig. 1.

Effect of AIP1 on the heart rate and action potentials of ventricular myocytes. (A) Does-dependent effect of AIP1 on the heart rate (All n=4 hearts). (B) Dose-dependent effect of AIP1 on APD. Superimposed traces of APs obtained using the patch-clamp technique under control conditions and in various concentrations of AIP1 with an apparent IC₅₀ value of APD₅₀ and APD₉₀ (n=4 cells). (C) Representative traces of APs under control conditions in the presence of 50 µg/ml AIP1. (D, E) Summary of the APD₅₀ and APD₉₀ as shown in (C). APD₅₀ and APD₉₀ mean the time required for repolarization to 50% and to 90% of basal membrane potential, respectively. ^*p<0.05 (n=6 cells).