Table 3.
Voxels (MNI Coordinates) with Significant Connectivity Associations with the Amygdala
Contrast | Region | Brodmann’s Area | Number of Voxels (kE) |
x | y | z | t(59) | p Correcteda |
---|---|---|---|---|---|---|---|---|
Connectivity in All Participants, Independent o f Group Status | ||||||||
Positive connectivity with left amygdala |
L medial OFC | 47 | 231 | −26 | 18 | −6 | 6.11 | .000 |
R medial OFC | 47 | 61 | 30 | 20 | −10 | 4.06 | .01 | |
L hippocampus | NA | 215 | −22 | −34 | −2 | 8.21 | .000 | |
R hippocampus | NA | 188 | 16 | −30 | −8 | 7.35 | .000 | |
L fusiform | 36 | 138 | −22 | −34 | −14 | 5.75 | .000 | |
R fusiform | 36 | 122 | 24 | −36 | −14 | 5.80 | .000 | |
Negative connectivity with left amygdala |
R dorsal ACC | 32 | 336 | 14 | 36 | 28 | 4.87 | .001 |
Positive connectivity with right amygdale |
L caudal ACC | 32/6b | 68 | 2 | −4 | 50 | 4.92 | .001 |
R caudal ACC | 32/6b | 47 | 4 | −2 | 48 | 4.33 | .005 | |
L hippocampus | NA | 194 | −28 | −8 | −16 | 9.44 | .000 | |
R hippocampus | NA | 164 | 30 | −6 | −16 | 11.26 | .000 | |
L fusiform | 37 | 138 | −34 | −54 | −16 | 5.36 | .000 | |
Negative connectivity with right amygdala |
L inferior PFC | 45 | 40 | −24 | 34 | 8 | 3.94 | .01 |
Connectivity in Adults vs. Adolescents | ||||||||
Greater positive connectivity with left amygdale |
L hippocampus | NA | 2 | −26 | −40 | 0 | 3.49 | .026 |
R hippocampus | NA | 19 | 30 | −34 | 2 | 4.09 | .005 |
L = left; R = right; OFC = orbito-frontal cortex; ACC = anterior cingulate cortex; PFC = prefrontal cortex; NA = Brodmann’s area not defined for this subcortical region.
All voxelwise t values are significant at α = .05 based on a small volume correction for multiple comparisons within each region.
Region extends to the Supplementary Motor Area (BA 6).