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. Author manuscript; available in PMC: 2010 Jul 13.
Published in final edited form as: Genes Chromosomes Cancer. 2008 Oct;47(10):853–859. doi: 10.1002/gcc.20589

Figure 2.

Figure 2

Pre-imatinib pathologic findings revealed a high risk primary gastric GIST with epithelioid morphology (A, HE, ×200) and diffuse reactivity for CD117 (B, ×200) and PDGFRA (C, ×200). The post-imatinib resection for peritoneal metastasis showed foci of viable spindle cells with abundant eosinophilic cytoplasm and strap cells, resembling an embryonal rhabdomyosarcoma phenotype (D, HE, ×400), which was negative for CD117, PDGFRA, (E,F, ×200), but strongly positive for skeletal muscle markers (G, desmin, ×200; H, myogenin, ×200). The mutation analysis of this sample revealed in addition to a PDGFRA exon 18 deletion, a BRAF exon 15 V600E substitution (I, ABI sequence).